Published : 2021-01-15

Preparation of highly pure cyclo-polylactides by optimization of the copper-catalyzed azide-alkyne cycloaddition reaction

Abstract

This work reports on the preparation of highly pure cyclo-polylactides (Mn ≈ 4 000 g • mol-1) by the optimization of the copper-catalyzed azide-alkyne cycloaddition (CuAAC) reaction applied on α-azide-ω-alkyne linear polylactide (PLA) precursors. By adjusting parameters such as the rate of reactant addition and the catalyst loading, monocyclic PLA's with a degree of purity of 93 % are obtained in few minutes. Highly pure monocycles (purity as high as 99.9 %) are also possibly prepared in few hours.



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Liénard, R., Josse, T., De Winter, J., Dubois, F., Gerbaux, P., & Coulembier, O. (2021). Preparation of highly pure cyclo-polylactides by optimization of the copper-catalyzed azide-alkyne cycloaddition reaction. Polimery, 62(4), 283-290. https://doi.org/10.14314/polimery.2017.283