The effect of liquid pore precursor addition on the morphology, porosity and mechanical properties of polylactide scaffolds was investigated. The scaffolds were obtained by inversion phase method in freeze extraction mode. Selected scaffolds were subjected to a cytotoxicity test using mouse fibroblastcells. It has been shown that the addition of pore precursors favorably changes the morphology of scaffolds at the cost of decreased mechanical strength. It has been found that polylactide cellular scaffolds can be successfully used forcell culture.
Kruk, A., Gadomska-Gajadhur, A., Dulnik, J., Rykaczewska, I., Ruśkowski, P., Sebai, A., & Synoradzki, L. (2021). Evaluation of functional properties and fibroblast growth on squashy cellular scaffolds. Polimery, 63(4), 270–274. https://doi.org/10.14314/polimery.2018.4.3
Biomineralization of poly‐l‐lactide spongy bone scaffolds obtained by freeze‐extraction method. Journal of Biomedical Materials Research Part B: Applied Biomaterials, 108(3), 868. 10.1002/jbm.b.34441
Agnieszka Gadomska-Gajadhur, Michał Wrzecionek, Grzegorz Matyszczak, Piotr Piętowski, Michał Więcław, Paweł Ruśkowski (2018)
Optimization of Poly(glycerol sebacate) Synthesis for Biomedical Purposes with the Design of Experiments. Organic Process Research & Development, 22(12), 1793. 10.1021/acs.oprd.8b00306
Aleksandra Kruk, Agnieszka Gadomska-Gajadhur, Judyta Dulnik, Paweł Ruśkowski (2022)
The influence of the molecular weight of polymer on the morphology, functional properties and L929 fibroblasts growth on polylactide membranes for tissue engineering. International Journal of Polymeric Materials and Polymeric Biomaterials, 71(1), 45. 10.1080/00914037.2020.1798440
Kruk A. (2019)
Influence of liquid pore precursors on morphology and mechanical properties of 3D scaffolds obtained by dry inversion phase method. Journal of Biomedical Materials Research Part B Applied Biomaterials, 107(4), 1079-1087. 10.1002/jbm.b.34200