Biodegradable copolymers with succinimide and lactic acid units. Part I. Synthesis possibilities

N. Tudorachi; A. P. Chiriac; R. Lipsa

Published : 2011-03-30

Vol. 56 No. 3 (2011)

Biodegradable copolymers with succinimide and lactic acid units. Part I. Synthesis possibilities

N. Tudorachi A. P. Chiriac R. Lipsa

Abstract

This paper present the possibility to achieve biodegradable copolymers with succinimide and lactic acid units via two different routes of synthesis processes. The first one (variant A) involves in situ copolymer synthesis using maleic anhydride, ammonium hydroxide and L(+)-lactic acid and the second (variant B) involves poly(succinimide) synthesis and then its modification with L(+)-lactic acid by mass polycondensation procedure. The prepared copolymers were characterized by IR and ¹H NMR spectroscopy, molecular weights and particle size distribution. The synthesized copolymers can be used as possible matrix to achieve some matrix/active principle systems with medical and pharmaceutical applications, especially owing to their biodegradability and biocompatibility.

Keywords

amfifilowe kopolimery ; sukcynoimid/kwas mlekowy ; synteza ; budowa chemiczna ; wymiary cząstek ; ciężar cząsteczkowy poly(succinimide-co-lactic acid) ; amphiphilic copolymers ; synthesis ; chemical structure ; particles dimensions ; molecular weight

Details

References

Statistics

Authors

Download files

PDF

Zasady cytowania

Tudorachi, N., Chiriac, A. P., & Lipsa, R. (2011). Biodegradable copolymers with succinimide and lactic acid units. Part I. Synthesis possibilities. Polimery, 56(3), 204-210. Retrieved from https://ichp.vot.pl/index.php/p/article/view/908

References

Frazza E. J., Schmitt E. E.: J. Biomed. Mater. Res. 1971, 1, 43.

2. Kobayashi H., Hyon S. H., Ikada Y.: J. Biomed. Mater. Res. 1991, 25, 1481.

3. Daniels A. U., Chang M. K. D., Andriano K. P.: J. Appl. Biomater. 1990, 1, 57.

4. Chasin M., Langer R.: “Biodegradable Polymers as Drug Delivery Systems”, Marcel Dekker, New York 1990.

5. Kissel T., Li Y. X., Volland C., Gorich S., Koneberg R.: J. Controlled Release 1996, 39, 315.

6. John G., Tsuda S., Morita M.: J. Polym. Sci., Part A: Polym. Chem. 1997, 35, 1901.

7. Nakayama A., Kawasaki N., Arvanitoyannis I., Iyoda J., Yamamoto N.: Polymer 1995, 36, 1295.

8. Kricheldorf H. R., Boettcher C.: Makromol. Chem. Macromol. Symp. 1993, 73, 47.

9. Li S. M., Rashkov I., Espartero J. L., Manolova N., Vert M.: Macromolecules 1996, 29, 57.

10. Benabdillah K. M., Coudane J., Boustta M., Engel R., Vert M.: Macromolecules 1999, 32, 8774.

11. Ouchi T., Shiratani M., Jinno M., Hirao M., Ohya Y.: Makromol. Chem., Rapid Commun. 1993, 14, 825.

12. Ouchi T., Nozaki T., Ishikawa A., Fujimoto I., Ohya Y.: J. Polym. Sci., Part A: Polym. Chem. 1997, 35, 377.

13. Kuciel S., Liber-Kneć A., Zajchowski S.: Polimery 2009, 54, 667.

14. Piórkowska E., Kuliński Z., Gadzinowska K.: Polimery 2009, 54, 83.

15. Ouchi T., Hamada A., Ohya Y.: Macromol. Chem. Phys. 1993, 200, 436.

16. Stridsberg K., Albertsson A. C.: Polymer 2000, 41, 7321.

17. Deng X., Zhu Z., Xiong C., Zhang L.: J. Polym. Sci., Part A: Polym. Chem. 1997, 35, 703.

18. Ouchi T., Miyazak H., Arimura H., Tasaka F., Hamada A.: J. Polym. Sci., Part A: Polym. Chem. 2002, 40, 1218.

19. Breitenbach A., Li Y. X., Kissel T.: J. Controlled Release 2000, 64, 167.

20. Tasaka F., Ohya Y., Ouchi T.: Macromolecules 2001, 34, 5494.

21. Tomida M., Nakato T., Mayumi K., Shibata M., Matsunami S., Kakuchi T.: Polymer 1996, 37, 4435.

22. US Pat. 5 296 578 (1994).

23. Piątkowski M., Bogdał D., Ondruschka B.: Polimery 2009, 54, 573.

24. Feng Y., Klee D., Hocker H.: Macromol. Chem. Phys. 2002, 203, 819.

25. Biela T., Duda A., Penczek S.: Macromol. Symp. 2002, 183, 1.

26. Save M., Schappacher M., Soum A.: Macromol. Chem. Phys. 2002, 203, 889.

Google Scholar

Citing articles via

Statistics

Total abstract views : 54

PDF Downloads : 53