Biodegradable copolymers with succinimide and lactic acid units. Part I. Synthesis possibilities

N. Tudorachi; A. P. Chiriac; R. Lipsa

Published : 2011-03-30

Vol. 56 No. 3 (2011)

Biodegradable copolymers with succinimide and lactic acid units. Part I. Synthesis possibilities

N. Tudorachi A. P. Chiriac R. Lipsa

Abstract

This paper present the possibility to achieve biodegradable copolymers with succinimide and lactic acid units via two different routes of synthesis processes. The first one (variant A) involves in situ copolymer synthesis using maleic anhydride, ammonium hydroxide and L(+)-lactic acid and the second (variant B) involves poly(succinimide) synthesis and then its modification with L(+)-lactic acid by mass polycondensation procedure. The prepared copolymers were characterized by IR and ¹H NMR spectroscopy, molecular weights and particle size distribution. The synthesized copolymers can be used as possible matrix to achieve some matrix/active principle systems with medical and pharmaceutical applications, especially owing to their biodegradability and biocompatibility.

Keywords

amfifilowe kopolimery ; sukcynoimid/kwas mlekowy ; synteza ; budowa chemiczna ; wymiary cząstek ; ciężar cząsteczkowy poly(succinimide-co-lactic acid) ; amphiphilic copolymers ; synthesis ; chemical structure ; particles dimensions ; molecular weight

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Tudorachi, N., Chiriac, A. P., & Lipsa, R. (2011). Biodegradable copolymers with succinimide and lactic acid units. Part I. Synthesis possibilities. Polimery, 56(3), 204–210. Retrieved from https://ichp.vot.pl/index.php/p/article/view/908

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