Published : 2024-07-04

Synthesis of double network nanohydrogel and its performance in release of doxorubicin

Abstract

The synthesis, properties, and performance of a controlled drug (doxorubicin, DOX) release system based on a double-network nanohydrogel (DNN) obtained from poly(acrylic acid) grafted onto sodium alginate (S-ALG) are described. The drug release behavior of DNNs was studied under different pH and temperature conditions. The DNNs were characterized by ultraviolet-visible (UV) spectroscopy, scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FT-IR), dynamic light scattering (DLS), and thermogravimetric analysis (TGA). DNN was confirmed to be suitable for use in controlled drug delivery systems.



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Rezanejade Bardajee, G., Noruzian, M., & Didehban, K. . (2024). Synthesis of double network nanohydrogel and its performance in release of doxorubicin. Polimery, 69(5), 300-311. https://doi.org/10.14314/polimery.2024.5.3