Thermoresponsive poly[oligo(ethylene glycol) methacrylate]s and their bioconjugates – synthesis and solution behavior

D. Szweda; R. Szweda; A. Dworak; B. Trzebicka

doi:10.14314/polimery.2017.298

Published : 2021-01-15

Vol. 62 No. 4 (2017)

Thermoresponsive poly[oligo(ethylene glycol) methacrylate]s and their bioconjugates – synthesis and solution behavior

D. Szweda R. Szweda A. Dworak B. Trzebicka

DOI: https://doi.org/10.14314/polimery.2017.298

Abstract

Growing interest for polymers containing oligoethylene side groups was observed within last years. Amongst these polymers the poly[oligo(ethylene glycol) methacrylate]s (POEGMAs) became most important. These polymers are biocompatible. Many of these polymers are thermoresponsive, when dissolved in water or physiological media, exhibit a narrow phase transition range and show only a small hysteresis. This review describes the synthesis and self-organization of homo- and copolymers of POEGMAs of different macromolecular topology. Data about the synthesis of thermoresponsive conjugates of POEGMAs with biologically active species and the possibility to use such conjugates for the synthesis of nanocarriers are discussed.

Keywords

thermoresponsive polymers ; poly[oligo(ethylene glycol) methacrylate]s ; aggregation ; bioconjugates polimery termoczułe ; poli(metakrylany glikoli oligoetylenowych) ; agregacja ; biokoniugaty

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Szweda, D., Szweda, R., Dworak, A., & Trzebicka, B. (2021). Thermoresponsive poly[oligo(ethylene glycol) methacrylate]s and their bioconjugates – synthesis and solution behavior. Polimery, 62(4), 298-310. https://doi.org/10.14314/polimery.2017.298

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D. Szweda help@libcom.pl

Affiliation
Centre of Polymer and Carbon Materials, Polish Academy of Sciences, M. Curie-Skłodowskiej 34, 41-819 Zabrze, Poland

R. Szweda

Affiliation
Centre of Polymer and Carbon Materials, Polish Academy of Sciences, M. Curie-Skłodowskiej 34, 41-819 Zabrze, Poland

A. Dworak

Affiliation
Centre of Polymer and Carbon Materials, Polish Academy of Sciences, M. Curie-Skłodowskiej 34, 41-819 Zabrze, Poland

B. Trzebicka

Affiliation
Centre of Polymer and Carbon Materials, Polish Academy of Sciences, M. Curie-Skłodowskiej 34, 41-819 Zabrze, Poland