Published : 2022-11-30

Vitamin E-loaded polymeric nanoparticles from biocompatible adipate-based copolymer obtained using the nanoprecipitation method

Abstract

An enzymatic synthesis of new aliphatic biopolyesters - poly(butylene adipate)-co-(dilinol adipate) (PBA-DLA) with the use of monomers obtained from natural sources was carried out. Lipase B from the strain Candida antarctica (CALB) was used as a biocatalyst. The chemical structure of the PBA-DLA copolyester was confirmed by 1H NMR. In vitro biological studies did not show its cytotoxic effect on mouse fibroblast cells. PBA-DLA nanoparticles obtained in a single-stage nanoprecipitation process were used to encapsulate hydrophobic α-tocopherol (α-TP), the main component of vitamin E, obtaining an encapsulation efficiency of 48−74% (EE%) depending on the concentration of α-TP (2.5 ; 5; 10 mg/ml), which was confirmed by dynamic light scattering (DLS) analysis, ultraviolet spectroscopy (UV-VIS) and 1H NMR.



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Sokołowska, M. ., Marchwiana, M. ., & El Fray, M. . (2022). Vitamin E-loaded polymeric nanoparticles from biocompatible adipate-based copolymer obtained using the nanoprecipitation method. Polimery, 67(11-12), 543–551. https://doi.org/10.14314/polimery.2022.11.1